Metabolism Alprazolam is extensively metabolized in people, generally by cytochrome P450 3A4 (CYP3A4), to two key active metabolites within the plasma: four-hydroxyalprazolam and α-hydroxyalprazolam. The plasma circulation levels of The 2 Lively metabolites are below 4% in the guardian. The claimed relative potencies in benzodiazepine receptor bin